A model to estimate the impact of changes in MMR vaccine uptake on inequalities in measles susceptibility in Scotland.

Monday, 29th of August 2016 Print

Stat Methods Med Res. 2016 Aug;25(4):1185-200. doi: 10.1177/0962280216660420.

A model to estimate the impact of changes in MMR vaccine uptake on inequalities in measles susceptibility in Scotland.

Napier G1 Lee D2 Robertson C3 Lawson A4 Pollock KG5.

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An article published in 1998 by Andrew Wakefield in The Lancet (volume 351 pages 637-641) led to concerns surrounding the safety of the measles mumps and rubella vaccine by associating it with an increased risk of autism. The paper was later retracted after multiple epidemiological studies failed to find any association but a substantial decrease in UK vaccination rates was observed in the years following publication. This paper proposes a novel spatio-temporal Bayesian hierarchical model with accompanying software (the R package CARBayesST) to simultaneously address three key epidemiological questions about vaccination rates: (i) what impact did the controversy have on the overall temporal trend in vaccination rates in Scotland; (ii) did the magnitude of the spatial inequality in measles susceptibility in Scotland increase due to the measles mumps and rubella vaccination scare; and (iii) are there any covariate effects such as deprivation that impacted on measles susceptibility in Scotland. The efficacy of the model is tested by simulation before being applied to measles susceptibility data in Scotland among a series of cohorts of children who were aged 2.5-4.5 in September of the years 1998 to 2014.


NB: This is a pay per view article URL: http://www.ncbi.nlm.nih.gov/pubmed/27566772

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